Your dog has osteoarthritis. The vet recommends Librela – a new injection that provides rapid pain relief. But then you read online about the side effects: incontinence, lameness, even neurological problems. Now you’re not sure what the right thing to do is.
You’re not alone. Thousands of dog owners are currently facing this decision.
TL;DR
- Librela is a new painkiller (monoclonal antibodies) – it works quickly, but the potential side effects worry many
- Natural alternatives such as green-lipped mussel, glucosamine or MSM take longer to work, but have no known serious side effects
- Both approaches can complement each other – or you can choose just one
- This article will help you make the right choice for your dog
What exactly is Librela?
Librela is a relatively new medicine for dogs with osteoarthritis. The active ingredient is called bedinvetmab – a so-called monoclonal antibody. It blocks a protein (NGF) that sends pain signals to the brain.
How does it work?
- Your dog receives an injection at the vet’s once a month
- The effects often start to be felt after just 2–7 days
- Many dogs are able to move around more comfortably again
That sounds brilliant at first. And for many dogs, Librela really is a huge relief.
However:
Reports are piling up in Facebook groups and forums from dog owners who’ve had negative experiences. The most commonly cited side effects are:
- Incontinence – dogs suddenly soiling the house
- Increased lameness – ironically, exactly the opposite of the desired effect
- Neurological symptoms – tremors, coordination problems, changes in behaviour
- Skin problems – itching, a rash at the injection site
- Loss of appetite – some dogs eat less
Important: Not every dog reacts this way. Many dogs tolerate Librela well and benefit enormously. But the reports are genuine – and they are a cause for concern for many dog owners.
Why are so many people looking for alternatives?
The Librela debate is dividing the dog-owning community. A Facebook group with over 60 comments on this topic shows that opinions vary widely.
In favour of Librela:
“My dog is like a different dog! He can finally run again.”
Against Librela:
“After the second injection, things got worse instead of better. Never again.”
What many dog owners have in common is the desire for a gentler solution – one that doesn’t interfere with the body’s own pain management system, one that can be stopped at any time, and one without injections.
This is where natural alternatives come into play.
Natural alternatives to Librela – what’s available?
1. Green-lipped mussel (Perna canaliculus)
The green-lipped mussel from New Zealand is the classic choice amongst natural joint remedies. It contains:
- Omega-3 fatty acids – which have anti-inflammatory effects
- Glycosaminoglycans – building blocks for cartilage and synovial fluid
- Antioxidants – protect the joints from further deterioration
What does the research say? Several studies show positive effects in dogs with osteoarthritis. Mobility improves and lameness decreases. However, it takes 4–6 weeks to see results.
2. Glucosamine and chondroitin
These two substances occur naturally in cartilage. As dietary supplements, they are said to help regenerate cartilage or at least slow down its breakdown.
- Glucosamine – promotes the formation of cartilage
- Chondroitin – binds water in the cartilage and keeps it elastic
The evidence from studies is mixed, but many vets recommend this combination as long-term support.
3. MSM (methylsulfonylmethane)
MSM is an organic sulphur compound. Sulphur is important for the formation of collagen – the structural framework of connective tissue.
Possible benefits:
- Anti-inflammatory
- Supports synovial fluid
- May relieve pain
4. Devil’s claw
This African plant has a long history of use for joint problems. It contains harpagosides – natural compounds with anti-inflammatory properties.
Please note: Devil’s claw may irritate the stomach. Not suitable for dogs with a sensitive digestive system.
5. Hyaluronic acid
Hyaluronic acid is a component of synovial fluid. It ensures that the joints remain ‘lubricated’ and function smoothly.

Librela vs. Natural – The Honest Comparison
| Criterion | Librela | Natural remedies |
|---|---|---|
| Onset of action | 2–7 days | 4–6 weeks |
| Administration | Monthly injection at the vet’s | Daily as a tablet/powder |
| Cost (per month) | €50–100 | €15–30 |
| Known side effects | Yes (see above) | Very rare, usually mild |
| Mechanism of action | Blocks pain signals | Supports cartilage and joints |
| Long-term data | Still limited (new medicine) | Decades of experience |
| Can be discontinued | Effect lasts for ~4 weeks | Can be stopped at any time |
Conclusion of this comparison:
Librela is a powerful remedy for acute, severe pain. If your dog is in distress and needs quick relief, it may be the right choice.
Natural remedies are better suited for:
- Long-term support
- Mild to moderate osteoarthritis
- Dogs where you want to avoid side effects
- As a supplement to other treatments
Can Librela and natural remedies be used together?
Yes! This is actually a popular strategy amongst vets.
Combined approach:
- Short-term: Librela for rapid pain relief
- Long-term: Natural joint remedies for support
- Goal: To reduce the Librela dose or stop it altogether
Some dog owners use Librela to manage acute pain – whilst simultaneously introducing natural support. Once the natural remedies take effect after a few weeks, the Librela injection can sometimes be reduced or paused.
Be sure to discuss this with your vet. Every dog is different, and only a professional can assess what’s best for your four-legged friend.
What should you look out for in natural joint remedies?
Not all products are the same. Here are the key quality features:
1. Ingredients:
- New Zealand green-lipped mussel (highest quality)
- A combination of several active ingredients (glucosamine, chondroitin, MSM, hyaluronic acid)
- Natural additives such as devil’s claw or ginger
2. No fillers:
- Look for short lists of ingredients
- Avoid products with high levels of grain or sugar as carriers
3. Dosage:
- Clear dosage instructions based on weight
- Sufficiently high levels of active ingredients (not under-dosed)
4. Origin:
- Made in Germany or the EU (strict quality controls)
- Transparent manufacturer information
5. Acceptance:
- Tablets that your dog enjoys eating – otherwise giving them daily will be a chore
Practical tips: How to get started with natural joint support
Weeks 1–2:
- Start with the recommended dose (based on weight)
- Give the tablets with their food or as a treat
- Keep a record of how your dog moves (videos are helpful!)
Weeks 3–4:
- You may start to see the first signs of improvement
- Look out for: getting up more easily, greater enthusiasm for movement, less limping
Weeks 5–6:
- The effects should now be more noticeable
- If not: be patient – some dogs need up to 8 weeks
In the long term:
- Natural joint supplements are intended for long-term use
- Do not stop using them as soon as your dog feels better – they continue to have a preventative effect
FAQ – Frequently Asked Questions
Is Librela dangerous for my dog?
Librela is an approved medicine and is generally safe. However, as with any medicine, there are potential side effects. Some dogs tolerate it without any problems, whilst others may be sensitive to it. Speak to your vet about the individual risks for your dog.
How quickly do natural joint remedies work?
Natural remedies take time. Expect it to take 4–6 weeks before you see noticeable improvements. They don’t work like painkillers, which simply suppress symptoms – they support the body in helping itself.
Can I simply stop giving Librela and switch to a natural remedy?
Please don’t do this without consulting your vet first! If your dog is in severe pain, they may still need support. A gradual transition – with the two treatments overlapping – is often better than an abrupt change.
How does the natural alternative compare in terms of cost?
Librela costs around €50–100 per month (depending on your dog’s size and your vet). High-quality joint tablets cost around €15–30 per month. So, in the long term, you’ll save significantly – often with comparable results for mild to moderate osteoarthritis.
Can young dogs take joint supplements too?
Yes, even as a preventative measure! Particularly for large breeds prone to hip dysplasia, early joint support can help delay or prevent problems.
Are there any side effects with natural remedies?
Very rarely, and usually mild. Some dogs may experience slightly looser stools at first. Devil’s claw can irritate the stomach. Overall, natural joint supplements are considered to be very well tolerated.
When should you see a vet?
Natural support is great – but it’s no substitute for the vet. Be sure to go if:
- Your dog suddenly becomes severely lame (not gradually, but from one day to the next)
- The joints are hot or swollen
- Your dog refuses to eat or seems listless
- The pain doesn’t improve despite 6–8 weeks of natural remedies
- You’re unsure just how bad the osteoarthritis really is
An X-ray will provide clarity on the condition of the joints. And sometimes a medication such as Librela is – at least temporarily – the right choice.
Natural products are a form of support, not a cure-all. With severe osteoarthritis, you may need both: rapid relief from medication AND long-term support from natural remedies.
Conclusion: Which is better – Librela or natural remedies?
There’s no one-size-fits-all answer. It depends on your dog:
Choose Librela if:
- Your dog is in severe, acute pain
- Rapid relief is more important than a long-term strategy
- Your vet recommends it and your dog has no risk factors
Choose natural alternatives if:
- The osteoarthritis is mild to moderate
- You want to avoid side effects
- You’re looking for a long-term, gentle solution
- You want to remain in control of the treatment
Ideally, a combination. Rapid relief with Librela, long-term support with natural remedies – with the aim of eventually relying solely on natural support.
Whatever you decide: you’re doing it out of love for your dog. And that’s what matters most.

Veddelholzer Dog Joint Tablets
With green-lipped mussel, glucosamine, chondroitin, MSM – 100% natural, made in Germany.
